Pembuatan Game “Jalan Ke Ibukota” Berbasis Android

Bermain game pada smartphone saat ini sedang menjadi bukti perkembangan game. Berbagai informasi dapat disampaikan dengan mudah menggunakan media game. Memberikan pengetahuan tentang budaya Indonesia lewat bermain game adalah cara paling menyenangkan. Selain itu juga dapat mengenalkan beberapa alat music tradisional,pakaian adat, masakan daerah. Hal ini akan lebih menyenangkan jika disajikan dalam bentuk game. Pada penelitian ini memperkenalkan cara edukasi baru menggunakan game RPG untuk mendidik masyarakat pengguna android akan selalu mudah untuk mengenal budaya Indonesia. Metode penelitian yang digunakan adalah metode Research and Development yang menggunakan tahapan penelitian (1) analisis menggunakan SWOT, untuk mengetahui kekuatan, kelemahan, peluang dan ancaman, (2) perancangan grafik dan flowchart game, (3) implementasi hasil perancangan game kedalam perangkat mobile dalam hal ini android, agar dapat digunakan kapan saja, (4) observasi meliputi tahap-tahap penelitian yang dilakukan dengan menggunakan metode pengembangan multimedia agar tampilan game RPG Jalan Ke Ibukota terlihat lebih menarik untuk dimainkan, (5) revisi, dan (6) uji coba produk

AN EFFICIENT AND PRIVACY PRESERVING OF DETECTING ONLINE GUESSING ATTACKS USING CAPTCHA

In our work we set up an innovative security primitive depending on unsolved tough problems. It is graphical password system family that include Captcha expertise as well as graphical passwords. Several number of graphical password schemes were proposed in literature in the traditional works. Captcha is a standard security method that has achieved a limited success when compared to cryptographic primitives on basis of tough math problems.   The systems deals quite a lot of online dictionary attacks on passwords that were most important security threat for a variety of online services such as protection against relay attacks, tough to shoulder-surfing attacks when combined with dual-view knowledge. Several schemes are converted to CaRP schemes which are clicked-based graphical passwords. The system is click-based graphical passwords, in which series of clicks on an image derives a password and require solving a challenge in each login and impact on usability is mitigated by means of adapting image complexity level based on login history of account as well as machine used to log in

Expert consensus on neurodevelopmental outcomes in pregnancy pharmacovigilance studies

Background: Exposure in utero to certain medications can disrupt processes of fetal development, including brain development, leading to a continuum of neurodevelopmental difficulties. Recognizing the deficiency of neurodevelopmental investigations within pregnancy pharmacovigilance, an international Neurodevelopmental Expert Working Group was convened to achieve consensus regarding the core neurodevelopmental outcomes, optimization of methodological approaches and barriers to conducting pregnancy pharmacovigilance studies with neurodevelopmental outcomes. Methods: A modified Delphi study was undertaken based on stakeholder and expert input. Stakeholders (patient, pharmaceutical, academic and regulatory) were invited to define topics, pertaining to neurodevelopmental investigations in medication-exposed pregnancies. Experts were identified for their experience regarding neurodevelopmental outcomes following medicinal, substances of misuse or environmental exposures in utero. Two questionnaire rounds and a virtual discussion meeting were used to explore expert opinion on the topics identified by the stakeholders. Results: Twenty-five experts, from 13 countries and professionally diverse backgrounds took part in the development of 11 recommendations. The recommendations focus on the importance of neurodevelopment as a core feature of pregnancy pharmacovigilance, the timing of study initiation and a core set of distinct but interrelated neurodevelopmental skills or diagnoses which require investigation. Studies should start in infancy with an extended period of investigation into adolescence, with more frequent sampling during rapid periods of development. Additionally, recommendations are made regarding optimal approach to neurodevelopmental outcome measurement, comparator groups, exposure factors, a core set of confounding and mediating variables, attrition, reporting of results and the required improvements in funding for potential later emerging effects. Different study designs will be required depending on the specific neurodevelopmental outcome type under investigation and whether the medicine in question is newly approved or already in widespread use. Conclusion: An improved focus on neurodevelopmental outcomes is required within pregnancy pharmacovigilance. These expert recommendations should be met across a complementary set of studies which converge to form a comprehensive set of evidence regarding neurodevelopmental outcomes in pregnancy pharmacovigilance

Knowledge, attitude and practice related to diabetes mellitus among general public

Background: Type 2 Diabetes Mellitus is a severe problem, which results in premature death and is a global epidemic. It can be prevented by changing the attitude, practices and bringing awareness towards the disease in the population. Aim: This study was conducted to evaluate knowledge, attitude and practice related to diabetes among general public in India. Materials and Methods: This study is a cross-sectional study and was carried out in health center in Telangana during the period 30 th March 2019 to 31 st March 2020. The sample size was 100. By convenience sampling from the outpatient department of the health centre, 100 patients were selected after considering inclusion and exclusion criteria. Results: 100 patients were involved in the study who were outpatients attending the health centre. 45% of patients were 18-35 years old, and 55% of patients were 36-65 years old. 58% were males, and 42% were females. 87% were aware of the organs which get damaged due to diabetes. 55% of patients were aware that the heart is affected, 85% of patients were aware that the kidney was affected, and 40% were aware that brain was affected by diabetes. Patients were aware of risk factors for diabetes mellitus namely obesity (70%), decreased physical activity (80%), family history of diabetes mellitus (65%), mental stress (62%) and consumption of sweets (93%) were aware was the causes of Diabetes mellitus. All patients were aware that diet control would keep blood sugar under normal levels. Conclusion: It is essential for health organisations to create more awareness through programs among the people towards T2DM as the high knowledge was not aligning with the attitude and practice towards the disease

Modelling of GPS signal scintillations with polynomial coefficients over the Indian region

167-174Performance of Global Positioning System (GPS) and other satellite based navigation systems can be degraded by the ionospheric scintillations of the signal. As the ionospheric scintillations behaviour varies with geographical location (latitude, longitude) and time, modelling is required for estimating and forecasting the scintillation. In this paper, amplitude and phase scintillations (S4 and σφ) of the GPS signal are modelled with the polynomial coefficients developed using the least square solution (LSS) with merit function. For the coefficients development, GPS satellites data from 17 stations of the GPS Aided Geo Augmented Navigation (GAGAN) system network in the Indian region is considered. It is found that estimated / predicted scintillations due to the developed coefficients are very close to the experimental (observed) data of Hyderabad receiver station (17.44°N, 78.47°E). The maximum deviation in predicted S4 and σφ is 0.03 and 0.3 rad, respectively. With the developed coefficients temporal, latitude and longitudinal variations of S4 and σφ are analysed for Hyderabad station (17.44°N, 78.47°E). </span

Renin-angiotensin-aldosterone system inhibitors and survival in patients with hypertension treated with immune checkpoint inhibitors.

Preclinical studies indicate that the concurrent use of inhibitors of the renin-angiotensin-aldosterone system (RAAS) may improve outcomes in broad groups of patients with cancer. There are limited data on the association between the use of RAAS inhibitors and outcomes among patients treated with immune checkpoint inhibitors (ICIs). We performed a retrospective study of all patients treated with an ICI in a single academic network. Of 10,903 patients, 5910 were on any anti-hypertensive medication. Of those on anti-hypertensive therapy, 3426 were prescribed a RAAS inhibitor during ICI treatment, and 2484 were prescribed other anti-hypertensive medications. The primary outcome was overall survival in the entire cohort and in sub-groups by cancer types. Thoracic cancer (34%) and melanoma (16%) were the most common types of cancer. Those prescribed a RAAS inhibitor were older, more frequently male, and had more cardiovascular risk factors. In a Cox proportional hazard model, the concurrent use of RAAS inhibitors was associated with better overall survival (hazard ratio (HR):0.92, [95% Confidence Interval (CI):0.85-0.99], P = .032). Patients with gastrointestinal (HR:0.82, [95% CI: 0.67-1.01], P = .057) and genitourinary cancer (HR:0.81, [95% CI:0.64-1.01], P = .067) had a non-statistically significant better overall survival. In this large retrospective study, patients with hypertension who were concomitantly taking a RAAS inhibitor during ICI therapy had better overall survival. This benefit was primarily noted among patients with gastrointestinal and genitourinary cancers. Prospective randomized trials are warranted to further evaluate and specify the benefit of RAAS inhibitors in patients with cancer who receive ICI therapy